CFRI-Funded Research Publications

CFRI-Funded Research Publications:
New Horizons and Elizabeth Nash Memorial Fellowship Programs

New Horizons:

  1. Conrad D, Haynes M, Salamon P, Rainey PB, Youle M, Rohwer F. Cystic Fibrosis therapy: a community ecology perspective. American Journal of Respiratory Cell and Molecular Biology. 48:150-156.
  2. Fischer H. Expression of dual oxidases and secreted cytokines in chronic rhinosinusitis. International Forum of Allergy and Rhinology. 3(5) pp376-383. 2013
  3. Finkbeiner WE, Zlock LT, Mehdi I, Widdicombe JH. Cultures of human tracheal gland cells of mucous or serous phenotype. In Vitro Cell Dev Biol Anim. May; 46(5):450-6. doi: 10.1007/s11626-009-9262-x. Epub 2009 Dec 9.
  4. Fischer H, Illek B, Sachs L, Finkbeiner WE, Widdicombe JH. CFTR and calcium-activated chloride channels in primary cultures of human airway gland cells of serous or mucous phenotype.  Am. J. Physiol Lung Cell Mol. Physiol. 299:  L585-594.
  5. Fu Z, Bettega K, Carroll S, Buchholz K, Machen T. Role of Ca2+ in responses of airway epithelia to Pseudomonas aeruginosa, flagellin, ATP, and thapsigargin. Am J Physiol Lung Cell Mol Physiol, Jan 2007; 292: L353-L364.
  6. He D, Wilborn TW, Falany JL, Li L, Falany CN. Repression of CFTR activity in human MMNK-1 cholangiocytes induces sulfotransferase 1E1 expression in co-cultured HepG2 hepatocytes.  Biochim Biophys Acta 1783: 2391-2397.
  7. Illek B,  Fu Z, Schwarzer C, Banzon T, Miller SS, Machen TE. Flagellin-Stimulated Cl- Secretion and Innate Immune Responses in Airway Epithelia: Role for p38. Am. J. Physiol., Lung Cell Molec Physiol. 295:L531-42.
  8. Li L, He D, Wilborn TW, Falany JL, Falany CN. Increased SULT1E1 activity in HepG2 hepatocytes decreases growth hormone stimulation of STAT5b phosphorylation. Steroids 74: 20-29.
  9. Lim YW, Schmieder R, Haynes M, Willner D, Furlan M, Youle M, Abbott K, Edwards R, Evangelista J, Conrad D, Rohwer F. Metagenomics and metatranscriptomics: windows on CF-associated viral and microbial communities. Journal of Cystic Fibrosis. 12:154-164.
  10. Machen TE. Innate immune response in CF airway epithelia: hyperinflammatory? Am J Physiol Cell Physiol, 1 Aug 2006; 291: C218-C230.
  11. Major TA, Panmanee W, Mortensen JE, Gray LD, Hoglen N, Hassett DJ. Sodium nitrite-mediated killing of the major cystic fibrosis pathogens Pseudomonas aeruginosa, Staphylococcus aureus, and Burkholderia cepacia under anaerobic planktonic and biofilm conditions.  Antimicrob Agents Chemother. 54:  4671-4677.
  12. Pena J, Fu Z, Schwarzer C, Machen TE. Pseudomonas aeruginosa inhibition of flagellin-activated NF-kappaB and interleukin-8 by human airway epithelial cells. Infect. Immun. 77: 2857-2865.
  13. Penterman J, Nguyen D, Anderson E, Staudinger BJ, Greenberg EP, Lam JS, Singh PK. Rapid Evolution of Culture-Impaired Bacteria during Adaptation to Biofilm Growth. Cell Reports 6, 293–300. 2014
  14. Fischer H. The G551D CFTR chloride channel spurs the development of personalized medicine. J. Physiol 592.9 pp 1907-1908. 2014
  15. Sargent RG, Suuki S, Gruenert DC. Nuclease-Mediated Double-Strand Break (DSB) Enhancement of Small Fragment Homologous Recombination (SFHR) Gene Modification in Human-Induced Pluripotent Stem Cells (hiPSCs). Methods in Molecular Biology. 1114 pp 279-290. 2014
  16. Schwarzer C, Fu Z, Shuai S, Babbar S, Zhao G, Li C, Machen TE. Pseudomonas aeruginosa homoserine lactone triggers apoptosis and Bak/Bax-independent release of mitochondrial cytochrome C in fibroblasts. Cellular Microbiology, 2014
  17. Schwarzer C, Ravishankar B, Patanwala M, Shuai S, Fu Z, Illek B, Fischer H, Machen TE. Thapsigargin blocks Pseudomonas aeruginosa homoserine lactone-induced apoptosis in airway epithelia. Am J Physiol Cell Physiol, May 2014; 306: C84-C855
  18. Schwarzer C, Fu Z, Patanwala M, Hum L, Lopez-Guzman M, Illek B, Kong W, Lynch SV, Machen TE. Pseudomonas aeruginosa biofilm-associated homoserine lactone C12 rapidly activates apoptosis in airway epithelia. Cell Microbiol 14:698-709.
  19. Schwarzer C, Wong S, Shi J, Matthes E, Illek B, Ianowski JP, Arant RJ, Isacoff E, Vais H, Foskett JK, Maiellaro I, Hofer AM, Machen TE. Pseudomonas aeruginosa Homoserine Lactone Activates Store-operated cAMP and Cystic Fibrosis Transmembrane Regulator-dependent Cl– Secretion by Human Airway Epithelia. J. Biol. Chem., Nov 2010; 285: 34850–34863.
  20. Schwarzer C, Fu Z, Fischer H, Machen TE. Redox-independent Activation of NF-B by Pseudomonas aeruginosa Pyocyanin in a Cystic Fibrosis Airway Epithelial. Cell Line J. Biol. Chem., Oct 2008; 283: 27144-27153.
  21. Su S, Panmanee W, Wilson JJ, Mahtani HK, Li Q, Hassett DJ et al. Catalase (KatA) Plays a Role in Protection against Anaerobic Nitric Oxide in Pseudomonas aeruginosa. PLoS ONE 9(3): e91813. doi:10.1371/journal.pone.0091813.
  22. Tseng J, Do J, Widdicombe JH, Machen TE. Innate immune responses of human tracheal epithelium to Pseudomonas aeruginosa flagellin, TNF-, and IL-1. Am J Physiol Cell Physiol, Mar 2006; 290: C678-C690.
  23. Widdicombe JH, Borthwell RM, Hajighasemi-Ossareh M, Lachowicz-Scroggins ME, Finkbeiner WE, Stevens JE, Modlin S. Chloride secretion by cultures of pig tracheal gland cells. Am J Physiol Lung Cell Mol Physiol. May 15;302(10):L1098-106. doi: 10.1152/ajplung.00253.2011. Epub 2012 Feb 24.
  24. Willner D, Haynes MR, Furlan M, Hanson N, Kirby B, Lim YW, Rainey PV, Schmieder R, Youle M, Conrad D, Rohwer F. Case studies of the spatial heterogeneity of DNA viruses in the cystic fibrosis lung. American Journal of Respiratory Cell and Molecular Biology. 46:127-131.
  25. Willner D, Haynes MR, Furlan M, Hanson N, Kirby B, Lim YW, Rainey PV, Schmieder R, Youle M, Conrad D, Rohwer F. Metagenomic analysis of the spatial distribution of viral communities in the cystic fibrosis lung.  American Journal of Respiratory Cell and Molecular Biology.
  26. Willner D, Haynes MR, Furlan M, Schmieder R, Lim YW, Rainey PV, Rohwer F, Conrad D. Spatial distribution of microbial communities in the cystic fibrosis lung. ISME Journal 1-4.
  27. Willner D, Furlan M, Haynes M, Schmieder R, Angly FE, Silva J, Tammadoni S, Nosrat B, Conrad D, Rohwer F. Metagenomic analysis of respiratory tract DNA viral communities in cystic fibrosis and non-cystic fibrosis individuals. PLoS One 4: e7370.
  28. Yu H, Zeidan YH, Wu BX, Jenkins RW, Flotte TR, Hannun YA, Virella-Lowell I. Defective acid sphingomyelinase pathway with Pseudomonas aeruginosa infection in cystic fibrosis. Am. J. Respir. Cell Mol. Biol. 41: 367-375.

 

Elizabeth Nash Memorial Post-Doctoral Fellowship:

  1. Blanchard E, Zlock L, Lao A, Mika D, Namkung W, Xie M, Scheitrum C, Gruenert DC, Verkman AS, Finkbeiner WE, Conti M, Richter W. Anchored PDE4 regulates chloride conductance in wild-type and F508-CFTR human airway epithelia. FASEB J, Feb 2014; 28: 791 – 801.
  2. Bucior I, Pielage JF, Engel JN. Pseudomonas aeruginosa pili and flagella mediate distinct binding and signaling events at the apical and basolateral surface of airway epithelium. PLoS pathogens, 2012 – dx.plos.org.
  3. Chandy G, Grabe M, Moore HP, Machen TE. Proton leak and CFTR in regulation of Golgi pH in respiratory epithelial cells. Am J Physiol Cell Physiol 2001;281:C908-C921.  PM: 11502568
  4. Chapman AL, Morrissey BM, Vasu VT et al. Myeloperoxidase-dependent oxidative metabolism of nitric oxide in the cystic fibrosis airway. J Cyst Fibros 2010;9:84-92.
PM: 20080069
  5. Chen Y, Yang N, Quinton PM, Chin WC. A new role for bicarbonate in mucus formation. Am J Physiol Lung Cell Mol Physiol 2010;299:L542-L549. Full text
  6. Chen Y, Zhao YH, Kalaslavadi TB et al. Genome-wide search and identification of a novel gel-forming mucin MUC19/Muc19 in glandular tissues. Am J Respir Cell Mol Biol 2004;30:155-165.
PM: 12882755
  7. Choi JY, Khansaheb M, Joo NS et al. Substance P stimulates human airway submucosal gland secretion mainly via a CFTR-dependent process. J Clin Invest 2009;119:1189-1200. PM: 19381016
  8. Choi JY, Joo NS, Krouse ME et al. Synergistic airway gland mucus secretion in response to vasoactive intestinal peptide and carbachol is lost in cystic fibrosis. J Clin Invest 2007;117:3118-3127. PM: 17853942
  9. Christianson JC, Shaler TA, Tyler RE, Kopito RR. OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. Nat Cell Biol 2008;10:272-282. PM: 18264092
  10. Christianson JC, Shaler TA, Tyler RE, Kopito RR. OS-9 and GRP94 deliver mutant 1-antitryspsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. Nature Cell Biology 10, 272 – 282 (2008).
  11. Conrad D, Haynes M, Salamon P, Rainey PB, Youle M, Rohwer F. Cystic Fibrosis Therapy: A Community Ecology Perspective. American Journal of Respiratory Cell and Molecular Biology, Vol. 48, No. 2 (2013), pp. 150-156.
  12. DeLaBarre B, Christianson JC, Kopito RR, Brunger AT. Central pore residues mediate the p97/VCP activity required for ERAD. Mol Cell 2006;22:451-462. PM: 16713576
  13. Derichs N, Jin BJ, Song Y, Finkbeiner WE, Verkman AS. Hyperviscous airway periciliary and mucous liquid layers in cystic fibrosis measured by confocal fluorescence photobleaching. FASEB J, Jul 2011;25(7):2325-32.
  14. Dubin RF, Robinson SK, Widdicombe JH. Secretion of lactoferrin and lysozyme by cultures of human airway epithelium. Am J Physiol Cell Mol Physiol, Apr 2004; 286: L750 – L755.
  15. Eiserich JP, Yang J, Morrissey BM, Hammock BD, Cross CE. Omics approaches in cystic fibrosis research: a focus on oxylipin profiling in airway secretions. Annals of the New York Academy of Sciences. Volume 1259, Environmental Stressors in Biology and Medicine, pages 1 – 9, July 2012.
  16. Fischer H, Schwarzer C, Illek B. Vitamin C controls the cystic fibrosis transmembrane conductance regulator chloride channel. Proc Natl Acad Sci U S A 2004;101:3691-3696.  
PM: 14993613
  17. Frank J, Roux J, Kawakatsu H et al. Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism. J Biol Chem 2003;278:43939-43950.  
PM: 12930837
  18. Fu Z, Bettega K, Carroll S, Buchholz KR, Machen TE. Role of CA2+ in responses of airway epithelia to Pseudomonas aeruginosa, flagellin, ATP, and thapsigargin. Am J Physiol Lung Cell Mol Physiol, Jan 2007; 292: L353 – L364.
  19. Gaggioli V, Schwarzer C, Fischer H. Expression of Nox1 in 3T3 cells increases cellular acid production but not proton conductance. Arch Biochem Biophys 2007;459:189-196. PM: 17234149
  20. Gernez Y, Dunn CE, Everson C, Mitsunaga E, Gudiputi L, Krasinska K, Davies ZA, Herzenberg LA, Tirouvanziam R, Moss RB. Blood basophils from cystic fibrosis patients with allergic bronchopulmonary aspergillosis are primed and hyper-responsive to stimulation by aspergillus allergens. Journal of Cystic Fibrosis, Volume 11, Issue 6, December 2012, 502 -510.
  21. Gruenert DC, Bruscia E, Novelli G, Colosimo A, Dallapiccola B, Sangiuolo F, Goncz KK. Sequence-specific modification of genomic DNA by small DNA fragments. J Clin Invest, 2003; 112(5): 637 – 641.
  22. Han MK, Huang YJ, LiPuma JJ, Boushey HA, Boucher RC, Cookson WO, Curtis JL, Erb-Downward J, Lynch SV, Sethi S, Toews GB, Young VB, Wolfgang MC, Huffnagle GB, Martinez FJ . REVIEW: Significance of the microbiome in obstructive lung disease. Thorax, May 2012; 67: 456 – 463.
  23. Howard M, Fischer H, Roux J et al. Mammalian osmolytes and S-nitrosoglutathione promote Delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) protein maturation and function. J Biol Chem 2003;278:35159-35167.  PM: 12837761
  24. Hybiske K, Fu Z, Schwarzer C et al. Effects of cystic fibrosis transmembrane conductance regulator and DeltaF508CFTR on inflammatory response, ER stress, and Ca2+ of airway epithelia. Am J Physiol Lung Cell Mol Physiol 2007;293:L1250-L1260. PM: 17827250
  25. Hybiske K, Ichikawa J, Huang V, Lory SJ, Machen TE. Cystic fibrosis airway epithelial cell polarity and bacterial flagellin determine host response to P. aeruginosa. Cellular Microbiology, 6: 49 – 62.
  26. Ianowski JP, Choi JY, Wine JJ, Hanrahan JW. Substance P stimulates CFTR-dependent fluid secretion by mouse tracheal submucosal glands. Pflugers Arch 2008;457:529-537. PM: 18509672
  27. Ianowski JP, Choi JY, Wine JJ, Hanrahan JW. Mucus secretion by single tracheal submucosal glands from normal and cystic fibrosis transmembrane conductance regulator knockout mice. J Physiol 2007;580:301-314. PM: 17204498
  28. Illek B, Fu Z, Schwarzer C, Banzon T, Miller SS, Machen TE. Flagellin-Stimulated CI-Secretion and Innate Immune Responses in Airway Epithelia. Am. J. Physiol., Lung Cell Molec Physiol, 2008; 295: L531-42.
  29. Jacob T, Lee RJ, Engel JN, Machen TE. Modulation of cytosolic Ca(2+) concentration in airway epithelial cells by Pseudomonas aeruginosa. Infect 2002;70(11);6399-6408.
PM: 12379720
  30. Joo NS, Cho HJ, Khansaheb M, Wine JJ. Hyposecretion of fluid from tracheal submucosal glands of CFTR-deficient pigs. J Clin Invest 2010;120:3161-3166. Full text
  31. Lee H, Pespeni M, Roux J, Dennery PA, Matthay MA, Pittet JF. HO-1 induction restores c-AMP-dependent lung epithelial fluid transport following severe hemorrhage in rats. FASEB J 2005;19:287-289. PM: 15550551
  32. Liu JY, Li N, Yang J et al. Metabolic profiling of murine plasma reveals an unexpected biomarker in rofecoxib-mediated cardiovascular events. Proc Natl Acad Sci U S A 2010;107:17017-17022. PM: 20837537
  33. Machen TE. Innate immune response in CF airway epithelia: hyperinflammatory? Am J Physiol Cell Physiol, Aug 2006; 291: C218 – C230.
  34. Machen TE, Chandy G, Wu M, Grabe M, Moore HP. Cystic fibrosis transmembrane conductance regulator and H+ permeability in regulation of Golgi pH. JOP 2001;2:229-236.
PM: 11875264
  35. Muchekehu RW, Quinton PM. A new role for bicarbonate secretion in cervico-uterine mucus release. J Physiol 2010;588:2329-2342. PM: 20478977
  36. Ning Y, Garcia MAS, and Quinton PM. Normal mucus formation requires cAMP-dependent HCO3– secretion and Ca2+-mediated mucin exocytosis. J. Physiol., Sep 2013; 591: 4581 – 4593.
  37. Nording ML, Yang J, Georgi K, Karbowski CH. Individual variation in lipidomic profiles of healthy subjects in response to omega-3 Fatty acids. PloS one, 2013 – dx.plos.org
  38. Pena J, Fu Z, Schwarzer C, Machen TE. Pseudomonas aeruginosa inhibition of flagellin-activated NF- B and Interleukin-8 by human airway epithelial cells. Infect. Immun., Jul 2009; 77: 2857 – 2865.
  39. Pittet JF, Lee H, Pespeni M, O’Mahony A, Roux J, Welch WJ. Stress-induced inhibition of the NF-kappaB signaling pathway results from the insolubilization of the IkappaB kinase complex following its dissociation from heat shock protein 90. J Immunol 2005;174:384-394. 
PM: 15611262
  40. Quinn RA, Wei Lim Y, Maughan H, Conrad D, Rohwer F, Whiteson KL. Biogeochemical Forces Shape the Composition and Physiology of Polymicrobial Communities in the Cystic Fibrosis Lung. mBio, Mar 2014; 5: e00956-13.
  41. Quinton PM. Role of epithelial HCO-transport in mucin secretion: lessons from cystic fibrosis. Am J Physiol Cell Physiol, Dec 2010; 299: C1222 – C 1233. PM: 20837537
  42. Quinton PM. Cystic fibrosis: impaired bicarbonate secretion and mucoviscidosis. The Lancet, Vol 372, Issue 9636, 2-8 August 2008, pages 415 – 417.
  43. Reddy MM, Wang XF, Gottschalk M, Jones K, Quinton PM. Normal CFTR Activity and Reversed Skin Potentials in Pseudohypoaldosteronism. J Membr Biol 2005;203:151-159. 
PM: 15986094
  44. Roux J, Kawakatsu H, Gartland B et al. Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway. J Biol Chem 2005;280:18579-18589. PM: 15755725
  45. Salinas D, Haggie PM, Thiagarajah JR et al. Submucosal gland dysfunction as a primary defect in cystic fibrosis. FASEB J 2005;19:431-433. PM: 15596485
  46. Salinas DB, Pedemonte N, Muanprasat C, Finkbeiner WF, Nielson DW, Verkman AS. CFTR involvement in nasal potential differences in mice and pigs studied using a thiazolidinone CFTR inhibitor. Am J Physiol Lung Cell Mol Physiol 2004;287:L936-L943. PM: 15246976
  47. Sana TG, Hachani A, Bucior I, Soscia C, Garvis S, Termine E, Engel J, Filloux A, Bleves S. The Second Type VI Secretion System of Pseudomonas aeruginosa Strain PAO1 is Regulated by Quorum Sensing and Fur and Modulates Internalization in Epithelial Cells. J Biol. Chem., Aug 2012; 287: 27095 – 27105.
  48. Schwarzer C, Fu Z, Shuai S, Babbar S, Zhao G, Li C, Machen TE. Pseudomonas aeruginosa homoserine lactone triggers apoptosis and Bak/Bax-independent release of mitochondrial cytochrome C in fibroblasts. Cellular Microbiology, 2014.
  49. Schwarzer C, Ravishankar B, Patanwala M, Shuai S, Fu Z, Illek B, Fischer H, Machen TE. Thapsigargin blocks Pseudomonas aeruginosa homoserine lactone-induced apoptosis in airway epithelia. Am J Physiol Cell Physiol, May 2014; 306: C844 – C855.
  50. Schwarzer C, Fu Z, Patanwala M, Hum L, Lopez-Guzman M, Illek B, Kong W, Lynch SV, Machen TE. Pseudomonas aeruginosa biofilm-associated homoserine lactone C12 rapidly activates apoptosis in airway epithelia. Cell Microbiol, 2012; 14: 698 – 709
  51. Schwarzer C, Wong S, Shi J, Mattes E, Illek B, Ianowski JP, Arant RJ, Isacoff E, Vais H, Foskett JK, Maiellaro I, Hofer AM, Machen TE. Pseudomonas aeruginosa homoserine lactone actives store-operated cAMP and cystic fibrosis transmembrane regulator-dependent CI secretion by human airway epithelia. J. Biol. Chem, Nov 2010; 285: 34850 – 34863.
  52. Schwarzer C, Fu Z, Fischer H, Machen TE. Redox-independent activation of NF- B by pseudomonas aeruginosa pyocyanin in a cystic fibrosis airway epithelial cell line. J. Biol. Chem., Oct 2008; 283: 27144 – 27153.
  53. Schwarzer C, Fischer H, Kim EJ et al. Oxidative stress caused by pyocyanin impairs CFTR Cl(-) transport in human bronchial epithelial cells. Free Radic Biol Med 2008;45:1653-1662. PM: 18845244
  54. Schwarzer C, Illek B, Suh JH, Remington SJ, Fischer H, Machen TE. Organelle redox of CF and CFTR-corrected airway epithelia. Free Radic Biol Med 2007;43:300-316. PM: 17603939
  55. Schwarzer C, Machen TE, Illek B, Fischer H. NADPH oxidase-dependent acid production in airway epithelial cells. J Biol Chem 2004;279:36454-36461.  PM: 15210697
  56. Swanson B, Savel R, Szoka F, Sawa T, Wiener-Kronish J. Development of a high throughput Pseudomonas aeruginosa epithelial cell adhesion assay. J Microbiol Methods 2003;52:361-366. PM: 12531505
  57. Tong Z, Illek B, Bhagwandin VJ, Verghese GM, Caughey GH. Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway epithelial cell line. Am J Physiol Lung Cell Mol Physiol 2004;287:L928-L935.
PM: 15246975
  58. Tsai HJ, Hwang SH, Morisseau C et al. Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs. Eur J Pharm Sci 2010;40:222-238. PM: 20359531
  59. Tseng J, Do J, Widdicombe JH, Machen TE. Innate immune responses of human tracheal epithelium to Pseudomonas aeruginosa, flagellin, TNF-, and IL-1. Am J Physiol Cell Physiol, March 2006; 290: C678 – C690.
  60. Vasu VT, de Cruz SJ, Houghton JS, Hayakawa KA, Morrissey BM, Cross CE, Eiserich JP. Evaluation of thiol-based antioxidant therapeutics in cystic fibrosis sputum: Focus on myeloperoxidase. Free Radic Res 45: 165-176.
  61. Verghese GM, Tong ZY, Bhagwandin V, Caughey GH. Mouse prostasin gene structure, promoter analysis, and restricted expression in lung and kidney. Am J Respir Cell Mol Biol 2004;30:519-529. PM: 12959947
  62. Wang L, Yang J, Guo L, Uyeminami D, Dong H, Hammock B, Pinkerton K. Use of a soluble epoxide hydrolase inhibitor in smoke-induced chronic obstructive pulmonary disease. Am J. Respiratory Cell and Molecular Biology, 2012.
  63. Wang X, Lytle C, Quinton PM. Predominant constitutive CFTR conductance in small airways. Respir Res 2005;6:7. PM: 15655076
  64. Wang XF, Reddy MM, Quinton PM. Effects of a new cystic fibrosis transmembrane conductance regulator inhibitor on Cl- conductance in human sweat ducts. Exp Physiol 2004;89:417-425. PM: 15131065
  65. Willner D, Furlan M, Schmieder R, Grasis JA, Pride DT, Relman DA, Angly FE, McDole T, Mariella Jr, R, Rohwer F, Haynes M. Metagenomic detection of phage-encoded platelet-binding factors in the human oral cavity. PNAS, Mar 2011; 108: 4547 – 4553.
  66. Wine JJ, Joo NS, Choi JY, Cho HJ, Krouse ME, Wu JV, Khansaheb M, Irokawa T, Ianowski J, Hanrahan JW, Cuthbert AW, Tran KV. Measurement of fluid secretion from intact airway submucosal glands. Methods in molecular biology, 2011; 742: p. 93-112. PMID:21547728
  67. Wine JJ. Acid in the airways. Focus on “Hyperacidity of secreted fluid from submucosal glands in early cystic fibrosis. Am J Phyisol Cell Physiol, Mar 2006; 290: C669 – C671.
  68. Wu H, Yang J, Su EM, Li L, Zhao C, Yang X, Gao Z. Lipoxin A4 and Platelet Activating Factor Are Involved in E. coli or LPS-Induced Lung Inflammation in CFTR-Deficient Mice.  PloS one, 2014 – dx.plos.org
  69. Xu X, Zhang D, Zhang H et al. Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. J Exp Med 2006;203:2907-2917. PM: 17158962
  70. Yang J, Bratt J, Franzi L, Liu J, Zhang G, Zeki AA, Vogel CFA, Williams K, Dong H, Lin Y, Hwang SH, Kenyon NK, Hammock BD. Soluble Epoxide Hydrolase Inhibitor Attenuates Inflammation and Airway Hyperresponsiveness in Mice. Am J Respir Cell Mol Biol, Jun 2014.
  71. Yang J, Eiserich JP, Cross CE, Morissey BM. Metabolomic profiling of regulatory lipid mediators in sputum from adult cystic fibrosis patients. Free Radical Biology and Medicine Volume 53, Issue 1, July 2012, Pages 160 – 171.
  72. Yang J, Dong H, Hammock BD. Profiling the regulatory lipids: another systemic way to unveil the biological mystery. Current opinion in lipidology, 2011.
  73. Yang J, Dong H, Hammock BD. 6 EETs and Oxo-ETE. Obstructive Airway.
  74. Yang J, Schmelzer K, Georgi K, Hammock BD. Quantitative profiling method for oxylipin metabolome by liquid chromatography electrospray ionization tandem mass spectrometry. Anal Chem 2009;81:8085-8093. PM: 19715299
  75. Zivkovic AM, Yang J, Georgi K, Hegedus C, Nording ML, O’Sullivan A, German JB, Hogg RJ, Weiss RH, Bay C, Hammock BD. Serum oxylipin profiles in IgA nephropathy patients reflect kidney functional alterations. Metabolomics, 2012 – Springer.

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